University of California San Francisco

Tobias Deuse, MD

Dr. Tobias Deuse
Tobias Deuse, MD

Professor of Surgery
The Julien I.E. Hoffman, M.D. Endowed Chair in Cardiac Surgery
Principal Investigator, TSI Lab
Division of Cardiac Surgery & Lung Transplantation
Department of Surgery, School of Medicine
University of California, San Francisco
Director, Minimally-Invasive Cardiac Surgery, UCSF Health
Surgical Director, Transcatheter Valve Program, UCSF Health
 

Academic Office:
500 Parnassus Ave, MUW 405, Box 0118
San Francisco, CA 94143-0118
Tel: (415) 353-8890
Email: [email protected] 
Admin: [email protected] 

Cardiac Surgery Program
400 Parnassus Avenue, Suite 501, Box 0957
San Francisco, California,  94143
Tel:415-353-1606
Fax: 415-353-1312

Biography

Dr. Tobias Deuse is a heart surgeon and the director of minimally invasive cardiac surgery at UCSF. He is known for his pioneering work in developing minimally invasive techniques for mitral valve repair.

Deuse earned his medical degree from the University of Würzburg in Germany. He received advanced training in heart and lung surgery at the University Hospital of Munich and University Heart Center Hamburg. After obtaining board certification in Germany as a heart surgeon, he completed a fellowship in lung and heart-lung transplantation with Stanford Medicine.

After returning to Germany in 2009, Deuse was appointed director of heart and lung transplantation at the University Heart Center Hamburg. He achieved international acclaim for his development of innovative approaches to heart failure surgery, most notably minimally invasive techniques for implanting ventricular assist systems. He also demonstrated that high success rates could be achieved in mitral valve repair utilizing fully robot-assisted endoscopic surgery. Also known as keyhole surgery, this approach has many benefits for the patient, including substantially reduced postsurgical pain, shorter hospital stays and faster recovery.

Deuse has received numerous honors, including election to the board of directors of the International Society for Heart and Lung Transplantation.

Education

Institution Degree Dept or School End Date
University of California Diversity, Equity, and Inclusion Champion Training 2019

Collaboration Interests

I am interested in:

  • physician scientist

Clinical Expertise

Minimally Invasive Mitral Valve Surgery

Minimally Invasive Aortic Valve Surgery

Minimally Invasive Atrial Septal Defect (ASD) Closure

Aortic Valve Repair & Replacement

Acute Aortic Dissection Repair

Heart Transplantation

Lung Transplantation

Ventricular Assist Devices (VAD)

Ventricular Aneurysm

Arrhythmia

Coronary Artery Bypass Grafting (CABG)

Off-Pump Coronary Artery Bypass (OPCAB)

Program Affiliations

UCSF Heart & Vascular Center

Grants and Funding

  • Hypo-immunogenic cardiomyocytes for myocardial repair | NIH | 2018-08-01 - 2022-06-30 | Role: Principal Investigator
  • Microgravity as model for immunological senescence and its impact on tissue stem cells and regeneration | NIH | 2017-06-15 - 2022-06-30 | Role: Co-Principal Investigator
  • Microgravity as model for immunological senescence and its impact on tissue stem cells and regeneration | NIH | 2017-06-15 - 2020-02-29 | Role: Co-Principal Investigator

Research Narrative

Dr. Deuse's research is focused on vascular biology and pathophysiology. His group was the among the first to elucdiate the novel pathways involved in the development of vascular intimal hyperplasia. Myointimal hyperplasia is a pathological process of the vascular system characterized by abnormal proliferation of smooth muscle cells of the vascular wall that leads to luminal obliteration and subsequent ischemia.

Myointimal hyperplasia may occur in patients after vessel injury during medical procedures (e.g. after balloon dilation or stent placement) or after pathological injury of the blood vessel (e.g. due to inflammation or toxic exposure). It can cause bypass graft failure and in-stent restenosis. To help prevent this and increase the success of treatments for vascular disease including coronary heart disease, his research group is working on the development of new preventive drug regimes and strategies.

Research Interests

Vascular Biology

Stem Cell Immunobiology

Transplant Immunology

Oxidative Stress and Apoptosis

Pulmonary Hypertension

Publications

MOST RECENT PUBLICATIONS FROM A TOTAL OF 149
  1. Hypoimmune CD19 CAR T cells evade allorejection in patients with cancer and autoimmune disease.
    Hu X, Beauchesne P, Wang C, Wong A, Deuse T, Schrepfer S, ARDENT and GLEAM investigators| | PubMed
  2. Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression.
    Carlsson PO, Hu X, Scholz H, Ingvast S, Lundgren T, Scholz T, Eriksson O, Liss P, Yu D, Deuse T, Korsgren O, Schrepfer S| | PubMed
  3. Hypoimmune FK binding protein 12-knockout CD19 CAR T cells achieve deep tissue B-cell depletion and control Nalm6 tumors in immunosuppressed humanized mice.
    Hu X, McAlister A, Kinder J, Johnson A, White K, Caruso CB, Wang C, Basco R, Gattis C, Friera A, Deuse T, Schrepfer S| | PubMed
  4. Hypoimmune CD19 CAR T cells treat allogeneic mice with features of spontaneous systemic lupus erythematosus.
    Hu X, White K, Olroyd AG, Friera A, Wang C, Caruso CB, Connolly AJ, Deuse T, Schrepfer S| | PubMed
  5. Inhibition of polymorphonuclear cells averts cytotoxicity against hypoimmune cells in xenotransplantation.
    Hu X, Tediashvili G, Gravina A, Stoddard J, McGill TJ, Connolly AJ, Deuse T, Schrepfer S| | PubMed
  6. Progress and challenges in developing allogeneic cell therapies.
    Deuse T, Schrepfer S| | PubMed
  7. Hydroxocobalamin for the treatment of vasoplegia after lung transplantation: A case series.
    Nguyen A, Bouajram R, Brzezinski M, Hassanipour S, Gordon D, Trinh B, Deuse T, Venado A, Hays S, Singer J, Kukreja J| | PubMed
  8. The HIP mouse and all of its organs are completely invisible to allogeneic immune cells.
    Hu X, White K, Olroyd AG, Wang C, Caruso CB, Gattis C, Young C, Connolly AJ, Deuse T, Schrepfer S| | PubMed
  9. Clinical Improvement With Transcatheter Edge-to-Edge Tricuspid Repair Irrespective of Right Atrial Pressure.
    Ya'Qoub L, Caughron H, Qasim A, Tolstrop K, Delling FN, Watt C, Nguyen T, Deuse T, Beygui RE, Mahadevan VS| | PubMed
  10. Hypoimmune islets achieve insulin independence after allogeneic transplantation in a fully immunocompetent non-human primate.
    Hu X, White K, Young C, Olroyd AG, Kievit P, Connolly AJ, Deuse T, Schrepfer S| | PubMed
  11. Four decades of progress in heart-lung transplantation: Two hundred seventy-one cases at a single institution.
    Elde S, Baccouche BM, Mullis DM, Leipzig MM, Deuse T, Krishnan A, Fawad M, Dale R, Walsh S, Padilla-Lopez A, Wesley B, He H, Yajima S, Zhu Y, Wang H, Guenthart BA, Shudo Y, Reitz BA, Woo YJ| | PubMed
  12. Lung Transplantation in Patients with Cystic Fibrosis: A Complex Task, A Changing Target.
    Loebe M, Deuse T, Sinha N, Koster A, Erdoes G| | PubMed
  13. Synthetic immune checkpoint engagers protect HLA-deficient iPSCs and derivatives from innate immune cell cytotoxicity.
    Gravina A, Tediashvili G, Zheng Y, Iwabuchi KA, Peyrot SM, Roodsari SZ, Gargiulo L, Kaneko S, Osawa M, Schrepfer S, Deuse T| | PubMed
  14. Hypoimmune induced pluripotent stem cells survive long term in fully immunocompetent, allogeneic rhesus macaques.
    Hu X, White K, Olroyd AG, DeJesus R, Dominguez AA, Dowdle WE, Friera AM, Young C, Wells F, Chu EY, Ito CE, Krishnapura H, Jain S, Ankala R, McGill TJ, Lin A, Egenberger K, Gagnon A, Michael Rukstalis J, Hogrebe NJ, Gattis C, Basco R, Millman JR, Kievit P, Davis MM, Lanier LL, Connolly AJ, Deuse T, Schrepfer S| | PubMed
  15. Human hypoimmune primary pancreatic islets avoid rejection and autoimmunity and alleviate diabetes in allogeneic humanized mice.
    Hu X, Gattis C, Olroyd AG, Friera AM, White K, Young C, Basco R, Lamba M, Wells F, Ankala R, Dowdle WE, Lin A, Egenberger K, Rukstalis JM, Millman JR, Connolly AJ, Deuse T, Schrepfer S| | PubMed
  16. Hypoimmune anti-CD19 chimeric antigen receptor T cells provide lasting tumor control in fully immunocompetent allogeneic humanized mice.
    Hu X, Manner K, DeJesus R, White K, Gattis C, Ngo P, Bandoro C, Tham E, Chu EY, Young C, Wells F, Basco R, Friera A, Kangeyan D, Beauchesne P, Dowdle WE, Deuse T, Fry TJ, Foster AE, Schrepfer S| | PubMed
  17. Protection of cell therapeutics from antibody-mediated killing by CD64 overexpression.
    Gravina A, Tediashvili G, Rajalingam R, Quandt Z, Deisenroth C, Schrepfer S, Deuse T| | PubMed
  18. Morbidity and Mortality Associated With Blood Transfusions in Elective Adult Cardiac Surgery.
    Sanaiha Y, Hadaya J, Verma A, Shemin RJ, Madani M, Young N, Deuse T, Sun J, Benharash P, University of California Cardiac Surgery Consortium| | PubMed
  19. Author Correction: Hypoimmunogenic derivatives of induced pluripotent stem cells evade immune rejection in fully immunocompetent allogeneic recipients.
    Deuse T, Hu X, Gravina A, Wang D, Tediashvili G, De C, Thayer WO, Wahl A, Garcia JV, Reichenspurner H, Davis MM, Lanier LL, Schrepfer S| | PubMed
  20. Intercostal Nerve Cryoanalgesia Versus Thoracic Epidural Analgesia in Lung Transplantation: A Retrospective Single-Center Study.
    Isaza E, Santos J, Haro GJ, Chen J, Weber DJ, Deuse T, Singer JP, Golden JA, Hays S, Trinh BN, Brzezinski M, Kukreja J| | PubMed
  21. Hypoimmune induced pluripotent stem cell-derived cell therapeutics treat cardiovascular and pulmonary diseases in immunocompetent allogeneic mice.
    Deuse T, Tediashvili G, Hu X, Gravina A, Tamenang A, Wang D, Connolly A, Mueller C, Mallavia B, Looney MR, Alawi M, Lanier LL, Schrepfer S| | PubMed
  22. Shock, Thrombus, TAVR: A Challenging TAVR With Large Left-Ventricular Thrombus.
    Blusztein D, Teng P, Deuse T, Mahadevan VS| | PubMed
  23. Immunomodulation Therapy Using Tolerogenic Macrophages in a Rodent Model of Pulmonary Hypertension.
    Guihaire J, Deuse T, Wang D, Spin JM, Blankenberg FG, Fadel E, Reichenspurner H, Schrepfer S| | PubMed
  24. The SIRPα-CD47 immune checkpoint in NK cells.
    Deuse T, Hu X, Agbor-Enoh S, Jang MK, Alawi M, Saygi C, Gravina A, Tediashvili G, Nguyen VQ, Liu Y, Valantine H, Lanier LL, Schrepfer S| | PubMed
  25. Outcomes of transcatheter aortic valve replacement in end stage liver and renal disease.
    Caughron H, Parikh D, Allison Z, Deuse T, Mahadevan VS| | PubMed
  26. Subxiphoid Hybrid Epicardial-Endocardial Atrial Fibrillation Ablation and LAA Ligation: Initial Sub-X Hybrid MAZE Registry Results.
    Ellis CR, Badhwar N, Tschopp D, Danter M, Jackson GG, Kerendi F, Walters T, Fang Q, Deuse T, Beygui R, Lee RJ| | PubMed
  27. Impact of Aortic Stenosis on Myofiber Stress: Translational Application of Left Ventricle-Aortic Coupling Simulation.
    Wisneski AD, Wang Y, Deuse T, Hill AC, Pasta S, Sack KL, Yao J, Guccione JM| | PubMed
  28. The H-Y Antigen in Embryonic Stem Cells Causes Rejection in Syngeneic Female Recipients.
    Hu X, Kueppers ST, Kooreman NG, Gravina A, Wang D, Tediashvili G, Schlickeiser S, Frentsch M, Nikolaou C, Thiel A, Marcus S, Fuchs S, Velden J, Reichenspurner H, Volk HD, Deuse T, Schrepfer S| | PubMed
  29. Risk Factors and Outcomes of Extracorporeal Membrane Oxygenation as a Bridge to Lung Transplantation.
    Kukreja J, Tsou S, Chen J, Trinh BN, Feng C, Golden JA, Hays S, Deuse T, Singer JP, Brzezinski M| | PubMed
  30. Frailty after lung transplantation is associated with impaired health-related quality of life and mortality.
    Venado A, Kolaitis NA, Huang CY, Gao Y, Glidden DV, Soong A, Sutter N, Katz PP, Greenland JR, Calabrese DR, Hays SR, Golden JA, Shah RJ, Leard LE, Kukreja J, Deuse T, Wolters PJ, Covinsky K, Blanc PD, Singer JP| | PubMed
  31. Impact of donor lung quality on post-transplant recipient outcome in the Lung Allocation Score era in Eurotransplant - a historical prospective study.
    Smits JM, Gottlieb J, Verschuuren E, Evrard P, Hoek R, Knoop C, Lang G, Kwakkel-van Erp JM, Vos R, Verleden G, Rondelet B, Hoefer D, Langer F, Schramm R, Hoetzenecker K, van Kessel D, Luijk B, Seghers L, Deuse T, Buhl R, Witt C, Strelniece A, Green D, de Vries E, Laufer G, Van Raemdonck D| | PubMed
  32. A Cryoinjury Model to Study Myocardial Infarction in the Mouse.
    Wang D, Tediashvili G, Hu X, Gravina A, Marcus SG, Zhang H, Olgin JE, Deuse T, Schrepfer S| | PubMed
  33. De novo mutations in mitochondrial DNA of iPSCs produce immunogenic neoepitopes in mice and humans.
    Deuse T, Hu X, Agbor-Enoh S, Koch M, Spitzer MH, Gravina A, Alawi M, Marishta A, Peters B, Kosaloglu-Yalcin Z, Yang Y, Rajalingam R, Wang D, Nashan B, Kiefmann R, Reichenspurner H, Valantine H, Weissman IL, Schrepfer S| | PubMed
  34. Bergeyella cardium: Clinical Characteristics and Draft Genome of an Emerging Pathogen in Native and Prosthetic Valve Endocarditis.
    Mulliken JS, Langelier C, Budak JZ, Miller S, Dynerman D, Hao S, Li LM, Crawford E, Lyden A, Woodworth MH, DeRisi JL, Desmond E, Browne C, Luu A, Grandis DJ, Grossman W, Deuse T, Melcher GP| | PubMed
  35. Hypoimmunogenic derivatives of induced pluripotent stem cells evade immune rejection in fully immunocompetent allogeneic recipients.
    Deuse T, Hu X, Gravina A, Wang D, Tediashvili G, De C, Thayer WO, Wahl A, Garcia JV, Reichenspurner H, Davis MM, Lanier LL, Schrepfer S| | PubMed
  36. Nontyphoidal Salmonella as a Cause of Mediastinal Abscess after Aortic Valve Replacement: A Case Report and Review of Postoperative Salmonella Infections.
    Spottiswoode N, Peluso MJ, Deuse T, Babik JM| | PubMed
  37. Analysis of Minimally Invasive Left Thoracotomy HVAD Implantation - A Single-Center Experience.
    Reichart D, Brand CF, Bernhardt AM, Schmidt S, Schaefer A, Blankenberg S, Reichenspurner H, Wagner FM, Deuse T, Barten MJ| | PubMed
  38. Lung allocation score: the Eurotransplant model versus the revised US model - a cross-sectional study.
    Smits JM, Nossent G, Evrard P, Lang G, Knoop C, Kwakkel-van Erp JM, Langer F, Schramm R, van de Graaf E, Vos R, Verleden G, Rondelet B, Hoefer D, Hoek R, Hoetzenecker K, Deuse T, Strelniece A, Green D, de Vries E, Samuel U, Laufer G, Buhl R, Witt C, Gottlieb J| | PubMed
  39. Normothermic ex-vivo preservation with the portable Organ Care System Lung device for bilateral lung transplantation (INSPIRE): a randomised, open-label, non-inferiority, phase 3 study.
    Warnecke G, Van Raemdonck D, Smith MA, Massard G, Kukreja J, Rea F, Loor G, De Robertis F, Nagendran J, Dhital KK, Moradiellos Díez FJ, Knosalla C, Bermudez CA, Tsui S, McCurry K, Wang IW, Deuse T, Lesèche G, Thomas P, Tudorache I, Kühn C, Avsar M, Wiegmann B, Sommer W, Neyrinck A, Schiavon M, Calabrese F, Santelmo N, Olland A, Falcoz PE, Simon AR, Varela A, Madsen JC, Hertz M, Haverich A, Ardehali A| | PubMed
  40. Hybrid Open Minimally Invasive Transcatheter Mitral Valve Replacement.
    Marcus SG, Mahadevan VS, Deuse T| | PubMed
  41. Balloon-based Injury to Induce Myointimal Hyperplasia in the Mouse Abdominal Aorta.
    Tediashvili G, Wang D, Reichenspurner H, Deuse T, Schrepfer S| | PubMed
  42. Hybrid and surgical procedures for the treatment of persistent and longstanding persistent atrial fibrillation.
    Sanchez JM, Al-Dosari G, Chu S, Beygui R, Deuse T, Badhwar N, Lee RJ| | PubMed
  43. Outcomes of Minimally Invasive Temporary Right Ventricular Assist Device Support for Acute Right Ventricular Failure During Minimally Invasive Left Ventricular Assist Device Implantation.
    Schaefer A, Reichart D, Bernhardt AM, Kubik M, Barten MJ, Wagner FM, Reichenspurner H, Philipp SA, Deuse T| | PubMed
  44. Thalidomide treatment prevents chronic graft rejection after aortic transplantation in rats - an experimental study.
    Miller KK, Wang D, Hu X, Hua X, Deuse T, Neofytou E, Renne T, Velden J, Reichenspurner H, Schrepfer S, Bernstein D| | PubMed
  45. Differences in Vascular Response between Balloon Overstretch and Stent Overexpansion in Nonatherosclerotic Porcine Coronary Arteries.
    Mitsutake Y, Reifart J, Pyun WB, Lyons JK, Deuse T, Schrepfer S, Ikeno F| | PubMed
  46. Gender differences and outcomes in left ventricular assist device support: The European Registry for Patients with Mechanical Circulatory Support.
    Magnussen C, Bernhardt AM, Ojeda FM, Wagner FM, Gummert J, de By TMMH, Krabatsch T, Mohacsi P, Rybczynski M, Knappe D, Sill B, Deuse T, Blankenberg S, Schnabel RB, Reichenspurner H| | PubMed
  47. The value of fluorine-18 deoxyglucose positron emission tomography scans in patients with ventricular assist device specific infections†.
    Bernhardt AM, Pamirsad MA, Brand C, Reichart D, Tienken M, Barten MJ, Schaefer A, Grahn H, Rybczynski M, Deuse T, Reichenspurner H, Wagner FM| | PubMed
  48. Lobar lung transplantation from deceased donors: A systematic review.
    Eberlein M, Reed RM, Chahla M, Bolukbas S, Blevins A, Van Raemdonck D, Stanzi A, Inci I, Marasco S, Shigemura N, Aigner C, Deuse T| | PubMed
  49. Vein Interposition Model: A Suitable Model to Study Bypass Graft Patency.
    Wang D, Tediashvili G, Pecha S, Reichenspurner H, Deuse T, Schrepfer S| | PubMed
  50. Orthotopic tracheal transplantation using human bronchus: an original xenotransplant model of obliterative airway disorder.
    Guihaire J, Itagaki R, Stubbendorff M, Hua X, Deuse T, Ullrich S, Fadel E, Dorfmüller P, Robbins RC, Reichenspurner H, Schumacher U, Schrepfer S| | PubMed
  51. Acute Pulmonary Artery Obstruction as the Primary Manifestation of a Rapidly Growing Intimal Sarcoma in a 54-Year-Old Patient.
    Westhofen S, Kugler C, Reichenspurner H, Deuse T| | PubMed
  52. A matched pairs analysis of non-rib-spreading, fully endoscopic, mini-incision technique versus conventional mini-thoracotomy for mitral valve repair.
    Westhofen S, Conradi L, Deuse T, Detter C, Vettorazzi E, Treede H, Reichenspurner H| | PubMed
  53. The Selective JAK1/3-Inhibitor R507 Mitigates Obliterative Airway Disease Both With Systemic Administration and Aerosol Inhalation.
    Deuse T, Hua X, Stubbendorff M, Spin JM, Neofytou E, Taylor V, Chen Y, Park G, Fink JB, Renne T, Kiefmann M, Kiefmann R, Reichenspurner H, Robbins RC, Schrepfer S| | PubMed
  54. The MANDELA study: A multicenter, randomized, open-label, parallel group trial to refine the use of everolimus after heart transplantation.
    Deuse T, Bara C, Barten MJ, Hirt SW, Doesch AO, Knosalla C, Grinninger C, Stypmann J, Garbade J, Wimmer P, May C, Porstner M, Schulz U| | PubMed
  55. Sex Differences in Immunology: More Severe Development of Experimental Pulmonary Hypertension in Male Rats Exposed to Vascular Endothelial Growth Factor Receptor Blockade.
    Guihaire J, Deuse T, Wang D, Fadel E, Reichenspurner H, Schrepfer S| | PubMed
  56. Distal Airway Stem Cells are Essential for Lung Regeneration.
    Deuse T, Schrepfer S| | PubMed
  57. Local MicroRNA Modulation Using a Novel Anti-miR-21-Eluting Stent Effectively Prevents Experimental In-Stent Restenosis.
    Wang D, Deuse T, Stubbendorff M, Chernogubova E, Erben RG, Eken SM, Jin H, Li Y, Busch A, Heeger CH, Behnisch B, Reichenspurner H, Robbins RC, Spin JM, Tsao PS, Schrepfer S, Maegdefessel L| | PubMed
  58. Mesenchymal stromal cell therapy: different sources exhibit different immunobiological properties.
    Neofytou E, Deuse T, Beygui RE, Schrepfer S| | PubMed
  59. Immunobiology of fibrin-based engineered heart tissue.
    Conradi L, Schmidt S, Neofytou E, Deuse T, Peters L, Eder A, Hua X, Hansen A, Robbins RC, Beygui RE, Reichenspurner H, Eschenhagen T, Schrepfer S| | PubMed
  60. Concomitant minimally invasive HVAD and transapical aortic valve implantation.
    Schaefer A, Treede H, Bernhardt A, Wagner FM, Reichenspurner H, Deuse T| | PubMed
  61. SCNT-derived ESCs with mismatched mitochondria trigger an immune response in allogeneic hosts.
    Deuse T, Wang D, Stubbendorff M, Itagaki R, Grabosch A, Greaves LC, Alawi M, Grünewald A, Hu X, Hua X, Velden J, Reichenspurner H, Robbins RC, Jaenisch R, Weissman IL, Schrepfer S| | PubMed
  62. Thymoglobulin induction in heart transplantation: patient selection and implications for maintenance immunosuppression.
    Zuckermann A, Schulz U, Deuse T, Ruhpawar A, Schmitto JD, Beiras-Fernandez A, Hirt S, Schweiger M, Kopp-Fernandes L, Barten MJ| | PubMed
  63. Isolated permanent right ventricular assist device implantation with the HeartWare continuous-flow ventricular assist device: first results from the European Registry for Patients with Mechanical Circulatory Support.
    Bernhardt AM, De By TM, Reichenspurner H, Deuse T| | PubMed
  64. Clinical experience of combined HeartWare ventricular assist device and implantable cardioverter defibrillator therapy.
    Pecha S, Wilke I, Bernhardt A, Hakmi S, Yildirim Y, Steven D, Reichenspurner H, Willems S, Deuse T, Aydin A| | PubMed
  65. HVAD implantation in right atrium-to-right pulmonary artery configuration.
    Deuse T, Kubik M, Reichenspurner H| | PubMed
  66. Introduction of the lung allocation score in Germany.
    Gottlieb J, Greer M, Sommerwerck U, Deuse T, Witt C, Schramm R, Hagl C, Strueber M, Smits JM| | PubMed
  67. Inducing myointimal hyperplasia versus atherosclerosis in mice: an introduction of two valid models.
    Stubbendorff M, Hua X, Deuse T, Ali Z, Reichenspurner H, Maegdefessel L, Robbins RC, Schrepfer S| | PubMed
  68. Dichloroacetate prevents restenosis in preclinical animal models of vessel injury.
    Deuse T, Hua X, Wang D, Maegdefessel L, Heeren J, Scheja L, Bolaños JP, Rakovic A, Spin JM, Stubbendorff M, Ikeno F, Länger F, Zeller T, Schulte-Uentrop L, Stoehr A, Itagaki R, Haddad F, Eschenhagen T, Blankenberg S, Kiefmann R, Reichenspurner H, Velden J, Klein C, Yeung A, Robbins RC, Tsao PS, Schrepfer S| | PubMed
  69. Minimally invasive implantation of biventricular assist devices.
    Deuse T, Reichenspurner H| | PubMed
  70. Do not touch the sternum--thoracotomy incisions for HVAD implantation.
    Deuse T, Reichenspurner H| | PubMed
  71. Efficacy of prophylactic intra-aortic balloon pump therapy in chronic heart failure patients undergoing cardiac surgery.
    Yildirim Y, Pecha S, Kubik M, Alassar Y, Deuse T, Hakmi S, Reichenspurner H| | PubMed
  72. Dual-chamber pacemaker implantation with left ventricular pacing in a patient with a right ventricular assist device.
    Sill B, Reichenspurner H, Deuse T| | PubMed
  73. HVAD continuous flow assist device for ischemic ventricular septal rupture.
    Bernhardt AM, Reichenspurner H, Deuse T| | PubMed
  74. Mechanically induced ventricular tachycardia by the HeartWare ventricular assist device.
    Yildirim Y, Pecha S, Reichenspurner H, Deuse T| | PubMed
  75. Everolimus in heart transplantation: an update.
    Hirt SW, Bara C, Barten MJ, Deuse T, Doesch AO, Kaczmarek I, Schulz U, Stypmann J, Haneya A, Lehmkuhl HB| | PubMed
  76. Bortezomib rescue therapy in a patient with recurrent antibody-mediated rejection after lung transplantation.
    Baum C, Reichenspurner H, Deuse T| | PubMed
  77. Granulocyte colony-stimulating factor therapy is associated with a reduced incidence of acute rejection episodes or allograft vasculopathy in heart transplant recipients.
    Vrtovec B, Haddad F, Pham M, Deuse T, Fearon WF, Schrepfer S, Leon S, Vu T, Valantine H, Hunt SA| | PubMed
  78. Immunological properties of extraembryonic human mesenchymal stromal cells derived from gestational tissue.
    Stubbendorff M, Deuse T, Hua X, Phan TT, Bieback K, Atkinson K, Eiermann TH, Velden J, Schröder C, Reichenspurner H, Robbins RC, Volk HD, Schrepfer S| | PubMed
  79. Minimal access median sternotomy for aortic valve replacement in elderly patients.
    Alassar Y, Yildirim Y, Pecha S, Detter C, Deuse T, Reichenspurner H| | PubMed
  80. Isolated permanent right ventricular assistance using the HVAD continuous-flow pump.
    Deuse T, Schirmer J, Kubik M, Reichenspurner H| | PubMed
  81. Aspergillus galactomannan antigen for diagnosis and treatment monitoring in cerebral aspergillosis.
    Soeffker G, Wichmann D, Loderstaedt U, Sobottka I, Deuse T, Kluge S| | PubMed
  82. ST-elevation myocardial infarction following heart transplantation as an unusual presentation of coronary allograft vasculopathy: a case report.
    Peter S, Hulme O, Deuse T, Vrtovec B, Fearon WF, Hunt S, Haddad F| | PubMed
  83. The potassium channel KCa3.1 as new therapeutic target for the prevention of obliterative airway disease.
    Hua X, Deuse T, Chen YJ, Wulff H, Stubbendorff M, Köhler R, Miura H, Länger F, Reichenspurner H, Robbins RC, Schrepfer S| | PubMed
  84. Severe bacterial superinfection based on influenza A (H1N1) pneumonia in a heart-lung transplant recipient.
    Yildirim Y, Pecha S, Sill B, Deuse T, Reichenspurner H| | PubMed
  85. Concomitant transcatheter aortic valve and left ventricular assist device implantation.
    Baum C, Seiffert M, Treede H, Reichenspurner H, Deuse T| | PubMed
  86. Late profound muscle weakness following heart transplantation due to Danon disease.
    Van Der Starre P, Deuse T, Pritts C, Brun C, Vogel H, Oyer P| | PubMed
  87. Significant reduction of acute cardiac allograft rejection by selective janus kinase-1/3 inhibition using R507 and R545.
    Deuse T, Hua X, Taylor V, Stubbendorff M, Baluom M, Chen Y, Park G, Velden J, Streichert T, Reichenspurner H, Robbins RC, Schrepfer S| | PubMed
  88. Clinical and functional correlates of early microvascular dysfunction after heart transplantation.
    Haddad F, Khazanie P, Deuse T, Weisshaar D, Zhou J, Nam CW, Vu TA, Gomari FA, Skhiri M, Simos A, Schnittger I, Vrotvec B, Hunt SA, Fearon WF| | PubMed
  89. Successful extracorporeal membrane oxygenation weaning after cardiac resynchronization therapy device implantation in a patient with end-stage heart failure.
    Pecha S, Yildirim Y, Reichenspurner H, Deuse T| | PubMed
  90. Human internal mammary artery (IMA) transplantation and stenting: a human model to study the development of in-stent restenosis.
    Hua X, Deuse T, Michelakis ED, Haromy A, Tsao PS, Maegdefessel L, Erben RG, Bergow C, Behnisch BB, Reichenspurner H, Robbins RC, Schrepfer S| | PubMed
  91. Cardiac paraganglioma: diagnostic and surgical challenges.
    Huo JL, Choi JC, DeLuna A, Lee D, Fleischmann D, Berry GJ, Deuse T, Haddad F| | PubMed
  92. Human leukocyte antigen I knockdown human embryonic stem cells induce host ignorance and achieve prolonged xenogeneic survival.
    Deuse T, Seifert M, Phillips N, Fire A, Tyan D, Kay M, Tsao PS, Hua X, Velden J, Eiermann T, Volk HD, Reichenspurner H, Robbins RC, Schrepfer S| | PubMed
  93. Immunobiology of naïve and genetically modified HLA-class-I-knockdown human embryonic stem cells.
    Deuse T, Seifert M, Phillips N, Fire A, Tyan D, Kay M, Tsao PS, Hua X, Velden J, Eiermann T, Volk HD, Reichenspurner H, Robbins RC, Schrepfer S| | PubMed
  94. Surgical technique of lower lobe lung transplantation.
    Deuse T, Sill B, von Samson P, Yildirim Y, Kugler C, Oldigs M, Klose H, Meierling S, Rabe KF, Reichenspurner H| | PubMed
  95. Bioluminescence imaging for assessment of immune responses following implantation of engineered heart tissue (EHT).
    Conradi L, Pahrmann C, Schmidt S, Deuse T, Hansen A, Eder A, Reichenspurner H, Robbins RC, Eschenhagen T, Schrepfer S| | PubMed
  96. Minimally invasive resection of a right atrial mass in a cardiac transplant recipient: a case report.
    Conradi L, Deuse T, Treede H, Seiffert M, Adam M, Koelble K, Costard-Jaeckle A, Wagner FM, Reichenspurner H| | PubMed
  97. Antibody response after a single dose of an AS03-adjuvanted split-virion influenza A (H1N1) vaccine in heart transplant recipients.
    Meyer S, Adam M, Schweiger B, Ilchmann C, Eulenburg C, Sattinger E, Runte H, Schlüter M, Deuse T, Reichenspurner H, Costard-Jäckle A| | PubMed
  98. Orthotopic aortic transplantation: a rat model to study the development of chronic vasculopathy.
    Stubbendorff M, Deuse T, Hammel A, Robbins RC, Reichenspurner H, Schrepfer S| | PubMed
  99. Transcatheter aortic valve implantation in a heart transplant recipient: a case report.
    Seiffert M, Meyer S, Franzen O, Conradi L, Baldus S, Schirmer J, Deuse T, Costard-Jaeckle A, Reichenspurner H, Treede H| | PubMed
  100. Immunogenicity and immunomodulatory properties of umbilical cord lining mesenchymal stem cells.
    Deuse T, Stubbendorff M, Tang-Quan K, Phillips N, Kay MA, Eiermann T, Phan TT, Volk HD, Reichenspurner H, Robbins RC, Schrepfer S| | PubMed
  101. Sustained inhibition of epsilon protein kinase C inhibits vascular restenosis after balloon injury and stenting.
    Deuse T, Koyanagi T, Erben RG, Hua X, Velden J, Ikeno F, Reichenspurner H, Robbins RC, Mochly-Rosen D, Schrepfer S| | PubMed
  102. Review of heart-lung transplantation at Stanford.
    Deuse T, Sista R, Weill D, Tyan D, Haddad F, Dhillon G, Robbins RC, Reitz BA| | PubMed
  103. Non-volume-loaded heart provides a more relevant heterotopic transplantation model.
    Tang-Quan KR, Bartos J, Deuse T, Churchill E, Schäfer H, Reichenspurner H, Mochly-Rosen D, Robbins RC, Schrepfer S| | PubMed
  104. Heterotopic and orthotopic tracheal transplantation in mice used as models to study the development of obliterative airway disease.
    Hua X, Deuse T, Tang-Quan KR, Robbins RC, Reichenspurner H, Schrepfer S| | PubMed
  105. Asymptomatic infection with novel influenza A/H1N1 virus in a heart transplant recipient.
    Meyer S, Ilchmann C, Adam M, Sattinger E, Siamkouris D, Arunagirinathan U, Deuse T, Wagner FM, Reichenspurner H, Costard-Jaeckle A| | PubMed
  106. Mechanisms behind local immunosuppression using inhaled tacrolimus in preclinical models of lung transplantation.
    Deuse T, Blankenberg F, Haddad M, Reichenspurner H, Phillips N, Robbins RC, Schrepfer S| | PubMed
  107. Changing trends in infectious disease in heart transplantation.
    Haddad F, Deuse T, Pham M, Khazanie P, Rosso F, Luikart H, Valantine H, Leon S, Vu TA, Hunt SA, Oyer P, Montoya JG| | PubMed
  108. LAD-ligation: a murine model of myocardial infarction.
    Kolk MV, Meyberg D, Deuse T, Tang-Quan KR, Robbins RC, Reichenspurner H, Schrepfer S| | PubMed
  109. Alternative technique for salvage of donor lungs with insufficient atrial cuffs.
    Yarbrough WM, Bates MJ, Deuse T, Tang DG, Robbins RC, Reitz BA, Mallidi HR| | PubMed
  110. Hepatocyte growth factor or vascular endothelial growth factor gene transfer maximizes mesenchymal stem cell-based myocardial salvage after acute myocardial infarction.
    Deuse T, Peter C, Fedak PW, Doyle T, Reichenspurner H, Zimmermann WH, Eschenhagen T, Stein W, Wu JC, Robbins RC, Schrepfer S| | PubMed
  111. Imaging in-stent restenosis: an inexpensive, reliable, and rapid preclinical model.
    Deuse T, Ikeno F, Robbins RC, Schrepfer S| | PubMed
  112. Heart-lung transplantation in situs inversus totalis.
    Deuse T, Reitz BA| | PubMed
  113. Right ventricular dysfunction predicts poor outcome following hemodynamically compromising rejection.
    Haddad F, Fisher P, Pham M, Berry G, Weisshaar D, Kuppahally S, Vrtovec B, Deuse T, Virani S, Fearon W, Valantine H, Hunt S| | PubMed
  114. A novel JAK3 inhibitor, R348, attenuates chronic airway allograft rejection.
    Velotta JB, Deuse T, Haddad M, Masuda E, Park G, Carroll D, Taylor V, Robbins RC, Schrepfer S| | PubMed
  115. Heart transplantation in situs inversus totalis.
    Deuse T, Reitz BA| | PubMed
  116. Twenty-year survivors of heart transplantation at Stanford University.
    Deuse T, Haddad F, Pham M, Hunt S, Valantine H, Bates MJ, Mallidi HR, Oyer PE, Robbins RC, Reitz BA| | PubMed
  117. Novel immunosuppression: R348, a JAK3- and Syk-inhibitor attenuates acute cardiac allograft rejection.
    Deuse T, Velotta JB, Hoyt G, Govaert JA, Taylor V, Masuda E, Herlaar E, Park G, Carroll D, Pelletier MP, Robbins RC, Schrepfer S| | PubMed
  118. Prevention and inhibition but not reversion of chronic allograft vasculopathy by FK778.
    Deuse T, Hoyt G, Koyanagi T, Robbins RC, Schrepfer S| | PubMed
  119. Introducing the first polymer-free leflunomide eluting stent.
    Deuse T, Erben RG, Ikeno F, Behnisch B, Boeger R, Connolly AJ, Reichenspurner H, Bergow C, Pelletier MP, Robbins RC, Schrepfer S| | PubMed
  120. Fluoroscopy to assess late heart and lung perforation by a permanent ventricular pacemaker lead. A case complicated by isolated hemothorax.
    Mortensen K, Aydin MA, Goldmann B, Deuse T, Willems S, Ventura R| | PubMed
  121. Effect of inhaled tacrolimus on cellular and humoral rejection to prevent posttransplant obliterative airway disease.
    Schrepfer S, Deuse T, Reichenspurner H, Hoffmann J, Haddad M, Fink J, Fischbein MP, Robbins RC, Pelletier MP| | PubMed
  122. Is the malononitrilamide FK778 better for the prevention of acute or chronic rejection?
    Deuse T, Schrepfer S, Pelletier MP, Fischbein MP, Robbins RC, Reichenspurner H| | PubMed
  123. Stem cell transplantation: the lung barrier.
    Schrepfer S, Deuse T, Reichenspurner H, Fischbein MP, Robbins RC, Pelletier MP| | PubMed
  124. Techniques for experimental heterotopic and orthotopic tracheal transplantations - When to use which model?
    Deuse T, Schrepfer S, Reichenspurner H, Hoyt G, Fischbein MP, Robbins RC, Pelletier MP| | PubMed
  125. Simplified protocol to isolate, purify, and culture expand mesenchymal stem cells.
    Schrepfer S, Deuse T, Lange C, Katzenberg R, Reichenspurner H, Robbins RC, Pelletier MP| | PubMed
  126. Experimental orthotopic tracheal transplantation: The Stanford technique.
    Schrepfer S, Deuse T, Hoyt G, Sheikh AY, Hoffmann J, Reichenspurner H, Robbins RC, Pelletier MP| | PubMed
  127. FK778 in experimental xenotransplantation: a detailed analysis of drug efficacy.
    Schrepfer S, Deuse T, Koch-Nolte F, Krieger T, Haddad M, Schäfer H, Pelletier MP, Robbins RC, Reichenspurner H| | PubMed
  128. Inhibition of restenosis development after mechanical injury: a new field of application for malononitrilamides?
    Schrepfer S, Deuse T, Sultan KR, Haddad M, Böger R, Münzel T, Schäfer H, Pelletier MP, Robbins RC, Reichenspurner H| | PubMed
  129. The selective estrogen receptor-beta agonist biochanin A shows vasculoprotective effects without uterotrophic activity.
    Schrepfer S, Deuse T, Münzel T, Schäfer H, Braendle W, Reichenspurner H| | PubMed
  130. Heparins increase endothelial nitric oxide bioavailability by liberating vessel-immobilized myeloperoxidase.
    Baldus S, Rudolph V, Roiss M, Ito WD, Rudolph TK, Eiserich JP, Sydow K, Lau D, Szöcs K, Klinke A, Kubala L, Berglund L, Schrepfer S, Deuse T, Haddad M, Risius T, Klemm H, Reichenspurner HC, Meinertz T, Heitzer T| | PubMed
  131. FK778: new cellular and molecular mechanisms of action.
    Schrepfer S, Deuse T, Koch-Nolte F, Detter C, Reichenspurner H| | PubMed
  132. Sirolimus and FK778: a comparison of two anti-proliferative immunosuppressants for prevention of experimental obliterative airway disease.
    Deuse T, Schrepfer S, Koch-Nolte F, Haddad M, Schäfer H, Detter C, Reichenspurner H| | PubMed
  133. Tracheal allograft transplantation in rats: the role of different immunosuppressants on preservation of respiratory epithelium.
    Schrepfer S, Deuse T, Sydow K, Schäfer H, Detter C, Reichenspurner H| | PubMed
  134. The phytoestrogen biochaninA weakens acute cardiac allograft rejection without affecting the reproductive system.
    Schrepfer S, Deuse T, Schäfer H, Koch-Nolte F, Braendle W, Reichenspurner H| | PubMed
  135. FK778 and tacrolimus prevent the development of obliterative airway disease after heterotopic rat tracheal transplantation.
    Deuse T, Schrepfer S, Koch-Nolte F, Haddad M, Schwedhelm E, Böger R, Schäfer H, Detter C, Reichenspurner H| | PubMed
  136. FK778, a novel immunosuppressive agent, reduces early adhesion molecule up-regulation and prolongs cardiac allograft survival.
    Schrepfer S, Deuse T, Schäfer H, Reichenspurner H| | PubMed
  137. Video and robotic-assisted minimally invasive mitral valve surgery: a comparison of the Port-Access and transthoracic clamp techniques.
    Reichenspurner H, Detter C, Deuse T, Boehm DH, Treede H, Reichart B| | PubMed
  138. FK778 attenuates lymphocyte-endothelium interaction after cardiac transplantation: in vivo and in vitro studies.
    Deuse T, Schrepfer S, Schäfer H, Koch-Nolte F, Schwedhelm E, Böger RH, Reichenspurner H| | PubMed
  139. The interaction between FK778 and tacrolimus in the prevention of rat cardiac allograft rejection is dose dependent.
    Deuse T, Schrepfer S, Reichenspurner H| | PubMed
  140. Immunosuppression with FK778 and mycophenolate mofetil in a rat cardiac transplantation model.
    Deuse T, Schrepfer S, Reichenspurner H| | PubMed
  141. Successful resection of a symptomatic right ventricular lipoma.
    Schrepfer S, Deuse T, Detter C, Treede H, Koops A, Boehm DH, Willems S, Lacour-Gayet F, Reichenspurner H| | PubMed
  142. Robotically assisted coronary artery bypass surgery with the ZEUS telemanipulator system.
    Boehm DH, Detter C, Arnold MB, Deuse T, Reichenspurner H| | PubMed
  143. Correlation between mononuclear infiltration and changes in VASP phosphorylation patterns after heterotopic cardiac transplantation in the rat.
    Deuse T, Lange V, Schrepfer S, Eigenthaler M, Reichart B, Walter U, Elert O| | PubMed
  144. Early and midterm results after coronary artery bypass grafting with and without cardiopulmonary bypass: which patient population benefits the most?
    Deuse T, Detter C, Samuel V, Boehm DH, Reichenspurner H, Reichart B| | PubMed
  145. New technique for chest opening in mice: U-sternotomy.
    Schrepfer S, Deuse T, Reichenspurner H| | PubMed
  146. Midterm results and quality of life after minimally invasive vs. conventional aortic valve replacement.
    Detter C, Deuse T, Boehm DH, Reichenspurner H, Reichart B| | PubMed
  147. Comparison of two stabilizer concepts for off-pump coronary artery bypass grafting.
    Detter C, Deuse T, Christ F, Boehm DH, Reichenspurner H, Reichart B| | PubMed
  148. Robotically-assisted coronary artery surgery with and without cardiopulmonary bypass - from first clinical use to endoscopic operation.
    Detter C, Boehm DH, Reichenspurner H, Deuse T, Arnold M, Reichart B| | PubMed
  149. Effect of hemodynamics on graft rejection in the heterotopic heart transplantation model.
    Lange V, Gassel AM, Deuse T, Ulrichs K, Silber RE| | PubMed